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Oxidative stress in carcinogenesis.

Authors
Caldwell-J; Kuempel-ED; Goldstein-BD
Source
Identification of Research Needs to Resolve the Carcinogenicity of High-priority IARC Carcinogens. Views and Expert Opinions of an IARC/NORA Expert Group Meeting, Lyon, France, 30 June - 2 July 2009. IARC Technical Publication No. 42. Lyon, France: International Agency for Research on Cancer, 2010 Jul; 42:213-214
NIOSHTIC No.
20037186
Abstract
Although several studies in humans have shown associations between biomarkers of oxidative stress and airborne particulate exposures (Han et al., 2005; Risom et al., 2005; Barregard et al., 2007; Valavanidis et al., 2009), evidence is still lacking on the role of oxidative stress in human carcinogenesis (Loft and Møller, 2006). Lack of specificity and need for standardized and validated methods indicate that careful evaluation is needed in considering the use of oxidative stress biomarkers in epidemiological studies. As for any other biomarkers, research is needed to examine the relationship between exposure to toxic agents and oxidative stress biomarkers, and between these biomarkers and risk of cancer, while controlling for the many individual factors that contribute to oxidative stress. Guidelines on standardizing the collection and measurement of oxidative stress biomarkers in humans (Horvath et al., 2005; ATS, 1999) will facilitate their effective use in epidemiological studies of human cancers.
Keywords
Cancer; Carcinogens; Carcinogenesis; Carcinogenicity; Biomarkers; Environmental-stress; Environmental-exposure; Environmental-hazards; Humans; Oxidative-enzymes; Oxidation; Oxidative-metabolism; Stress; Fatigue; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-limits; Chemical-analysis; Chemical-hypersensitivity
CAS No.
10102-43-9
Publication Date
20100701
Document Type
Book or book chapter
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISBN No.
9789283224495
ISSN
1012-7348
NIOSH Division
EID
Source Name
Identification of Research Needs to Resolve the Carcinogenicity of High-priority IARC Carcinogens. Views and Expert Opinions of an IARC/NORA Expert Group Meeting, Lyon, France, 30 June - 2 July 2009, IARC Technical Publication No. 42
State
NC; OH; PA
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