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Organophosphorus chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics.

Authors
Hodgson-E; Rose-RL
Source
Drug Metab Rev 2006 38(1-2):149-162
NIOSHTIC No.
20037175
Abstract
Although it has been known for some time that organophosphate chemicals containing the P = S moiety are irreversible inhibitors of cytochrome P450, this knowledge has not been generally applied to the human metabolism of xenobiotics. Recent studies have demonstrated that organophosphate insecticides containing this moiety are potent inhibitors of the metabolism of both xenobiotics and endogenous substrates by human liver microsomes and by specific human cytochrome P450 isoforms.
Keywords
Chemical-analysis; Chemical-binding; Chemical-composition; Chemical-hypersensitivity; Chemical-indicators; Chemical-reactions; Chemical-structure; Chemical-synthesis; Chemical-warfare-agents; Exposure-assessment; Exposure-levels; Exposure-limits; Humans; Agricultural-chemicals; Agricultural-workers; Agriculture; Work-analysis; Work-environment; Worker-health; Workplace-monitoring; Workplace-studies; Liver; Liver-damage; Liver-disorders; Liver-enzymes; Liver-function; Liver-tissue; Microbiology; Microchemistry; Microsomal-enzymes; Organic-chemicals; Organo-nitrogen-compounds; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Insecticide-poisoning; Insecticides; Pesticide-residues; Pesticides; Pesticides-and-agricultural-chemicals; Public-health; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-health-monitoring; Environmental-pollution; Animal-studies; Animals; Health-hazards; Health-protection; Health-standards; Author Keywords: Carbaryl; Chlorpyrifos; Chlorpyrifos oxon; Cytochrome P450 (CYP); DEET; Estradiol; Human CYP isoforms; Human liver microsomes; Organophosphorus insecticides; Permethrin; Testosterone
Contact
Ernest Hodgson, Department of Environmental and Molecular Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695, USA
CODEN
DMTRAR
CAS No.
63-25-2; 52645-53-1
Publication Date
20060101
Document Type
Journal Article
Email Address
ernest_hodgson@ncsu.edu
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007551
Issue of Publication
1-2
ISSN
0360-2532
Source Name
Drug Metabolism Reviews
State
NC
Performing Organization
North Carolina State University-Raleigh
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