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Occupational exposure limits for nanomaterials: state of the art.

Authors
Schulte-PA; Murashov-V; Zumwalde-R; Kuempel-ED; Geraci-CL
Source
J Nanoparticle Res 2010 Aug; 12(6):1971-1987
NIOSHTIC No.
20037147
Abstract
Assessing the need for and effectiveness of controlling airborne exposures to engineered nanomaterials in the workplace is difficult in the absence of occupational exposure limits (OELs). At present, there are practically no OELs specific to nanomaterials that have been adopted or promulgated by authoritative standards and guidance organizations. The vast heterogeneity of nanomaterials limits the number of specific OELs that are likely to be developed in the near future, but OELs could be developed more expeditiously for nanomaterials by applying dose-response data generated from animal studies for specific nanoparticles across categories of nanomaterials with similar properties and modes of action. This article reviews the history, context, and approaches for developing OELs for particles in general and nanoparticles in particular. Examples of approaches for developing OELs for titanium dioxide and carbon nanotubes are presented and interim OELs from various organizations for some nanomaterials are discussed. When adequate dose-response data are available in animals or humans, quantitative risk assessment methods can provide estimates of adverse health risk of nanomaterials in workers and, in conjunction with workplace exposure and control data, provide a basis for determining appropriate exposure limits. In the absence of adequate quantitative data, qualitative approaches to hazard assessment, exposure control, and safe work practices are prudent measures to reduce hazards in workers.
Keywords
Nanotechnology; Risk-analysis; Aerosols; Aerosol-particles; Standards; Dose-response; Dosimetry; Author Keywords: Nanomaterials; Regulation; Risk assessment; Occupational safety and health; Carbon nanotubes; Control banding
Contact
P. A. Schulte, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA
CODEN
JNARFA
CAS No.
13463-67-7; 7440-44-0
Publication Date
20100801
Document Type
Journal Article
Email Address
PSchulte@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1388-0764
NIOSH Division
EID
Source Name
Journal of Nanoparticle Research
State
OH
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