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Exposure period considerations in developmental neurotoxicity assessments.

Authors
Nelson-BK
Source
Teratology 1991 May; 43(5):410
NIOSHTIC No.
20037024
Abstract
This presentation will discuss primary factors to address in determining exposure and dosing regimens, as well as exposure durations, in planning developmental neurotoxicity investigations. Whether the investigator employs a single dose during pregnancy, or continuous dosing prior to and throughout pregnancy (as well as during early postnatal development), the following primary factors should be addressed: 1) Purpose of the study (e.g., descriptive [such as screening] or investigative [such as determining the mechanism of action]); 2) physicochemical properties of the test compound that affect its pharmacokinetics and pharmacodynamics; 3) ability of the test compound to induce or inhibit metabolic enzymes; 4) appropriateness and characteristics of the test species; 5) limiting factors, including the availability of test compound for evaluation (e.g ., small quantities of a newly synthesized drug); and, 6) a number of general, miscellaneous factors (e.g., complications of maternal or fetal toxicity from extended dosing durations). Selection of exposure and dosing regimen (s), and exposure durations, most appropriate for a particular developmental neurotoxicity assessment requires careful attention to these factors.
Keywords
Toxicology; Analytical-methods; Analytical-processes; Neurotoxic-effects; Neurotoxicity; Screening-methods; Dose-response; Exposure-assessment; Exposure-levels; Exposure-methods; Exposure-limits; Prenatal-exposure; Developmental-disorders
CODEN
TJADAB
Publication Date
19910501
Document Type
Abstract
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0040-3709
NIOSH Division
DBBS
Source Name
Teratology
State
OH; FL
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