Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Chronic boron exposure and human semen parameters.

Authors
Robbins-WA; Xun-L; Jia-J; Kennedy-N; Elashoff-DA; Ping-L
Source
Reprod Toxicol 2010 Apr; 29(2):184-190
NIOSHTIC No.
20037010
Abstract
Boron found as borates in soil, food, and water has important industrial and medical applications. A panel reviewing NTP reproductive toxicants identified boric acid as high priority for occupational studies to determine safe versus adverse reproductive effects. To address this, we collected boron exposure/dose measures in workplace inhalable dust, dietary food/fluids, blood, semen, and urine from boron workers and two comparison worker groups (n = 192) over three months and determined correlations between boron and semen parameters (total sperm count, sperm concentration, motility, morphology, DNA breakage, apoptosis and aneuploidy). Blood boron averaged 499.2 ppb for boron workers, 96.1 and 47.9 ppb for workers from high and low environmental boron areas (p < 0.0001). Boron concentrated in seminal fluid. No significant correlations were found between blood or urine boron and adverse semen parameters. Exposures did not reach those causing adverse effects published in animal toxicology work but exceeded those previously published for boron occupational groups.
Keywords
Boron-compounds; Occupational-health; Environmental-exposure; Reproductive-effects; Workers; Worker-health; Occupational-exposure; Spermatozoa; Exposure-assessment; Author Keywords: Boron; Borates; Boric acid; Semen; Sperm; Occupational health; Reproduction
Contact
Wendie A. Robbins, Center for Occupational and Environmental Health, University of California, Los Angeles, 5-254 Factor Bldg, Mailcode 956919, Los Angeles, CA 90095-6919, United States
CODEN
REPTED
CAS No.
7440-42-8
Publication Date
20100401
Document Type
Journal Article
Email Address
wrobbins@sonnet.ucla.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007575
Issue of Publication
2
ISSN
0890-6238
Source Name
Reproductive Toxicology
State
CA
Performing Organization
University of California, Los Angeles
TOP