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Pesticide metabolism in humans, including polymorphisms.

Authors
Rose-RL; Tang-J; Choi-J; Cao-Y; Usmani-A; Cherrington-N; Hodgson-E
Source
Scand J Work, Environ & Health 2005 Jan; 31(S1):156-163
NIOSHTIC No.
20036987
Abstract
Recent epidemiologic studies involving Gulf War veterans or agricultural workers suggest that pesticide-pesticide or pesticide-drug interactions may be related to Gulf-War-related illnesses or elevated cancer risks, respectively. Metabolic interactions are one of many potential mechanisms requiring exploration in humans. The goal of the studies is to characterize important metabolic profiles of selected pesticides and examine potential interactions to characterize human risks associated with exposure. Pesticides examined using human liver microsomes and cytosolic fractions included chlorpyrifos, carbaryl and permethrin. The metabolic pathways involved include cytochrome P450 monooxygenases (CYP), esterases, and alcohol and aldehyde dehydrogenases. Specific isoforms and some polymorphic enzymes were characterized. Pesticide-pesticide interactions with metabolizing enzymes were demonstrated. Exposure of human hepatocytes to chlorpyrifos and permethrin demonstrated their potential to induce CYP isoforms using the bDNA (branched deoxyribonucleic acid) assay [used to monitor mRNA (messenger ribonucleic acid) levels]. These studies suggest that knowledge of human metabolic pathways will provide information that can aid the risk assessment process.
Keywords
Insecticides; Epidemiology; Agricultural-chemicals; Agricultural-industry; Agricultural-machinery; Agricultural-processes; Agricultural-products; Agricultural-workers; Agriculture; Pesticide-industry; Pesticide-residues; Pesticide-strips; Pesticides; Pesticides-and-agricultural-chemicals; Humans; Exposure-levels; Exposure-limits; Exposure-methods; Respirable-dust; Respiration; Respirators; Respiratory-equipment; Respiratory-hypersensitivity; Author Keywords: carbaryl; chlorpyrifos; cytochrome P450; esterase; induction inhibition; insecticide; permethrin
Contact
Department of Environmental and Molecular Toxicology, Box 7633, Raleigh, NC, 27695
CODEN
SWEHDO
CAS No.
63-25-2; 2921-88-2; 52645-53-1
Publication Date
20050101
Document Type
Journal Article
Email Address
randy_rose@ncsu.edu
Funding Type
Cooperative Agreement
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007551
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment and Health
State
AZ; NC
Performing Organization
East Carolina University
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