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Research recommendations for selected IARC-classified agents.

Authors
Ward-EM; Schulte-PA; Straif-K; Hopf-NB; Caldwell-JC; Carreón-T; Demarini-DM; Fowler-BA; Goldstein-BD; Hemminki-K; Hines-CJ; Husgafvel-Pursiainen-K; Kuempel-E; Lewtas-J; Lunn-RM; Lynge-E; McElvenny-DM; Muhle-H; Nakajima-T; Robertson-LW; Rothman-N; Ruder-AM; Schubauer-Berigan-MK; Siemiatycki-J; Silverman-D; Smith-MT; Sorahan-T; Steenland-K; Stevens-RG; Vineis-P; Hoar Zahm-S; Zeise-L; Cogliano-VJ
Source
Environ Health Perspect 2010 Jun; 118(10):1355-1362
NIOSHTIC No.
20036985
Abstract
OBJECTIVES: There are some common occupational agents and exposure circumstances where evidence of carcinogenicity is substantial but not yet conclusive for humans. The objectives are to identify research gaps and needs for twenty agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. DATA SOURCES: A systematic review was conducted of new data published since the most recent pertinent IARC monograph meeting. DATA EXTRACTION: Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches. DATA SYNTHESIS: Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress and immuno- and hormonal modulation. CONCLUSIONS: Studies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.
Keywords
Animals; Animal-studies; Laboratory-animals; Carcinogens; Carcinogenesis; Carcinogenicity; Epidemiology; Statistical-analysis; Author Keywords: animal; carcinogen; carcinogenesis; epidemiology; human; IARC; mechanisms of carcingenicity; occupational;
Contact
Elizabeth M. Ward PhD., Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street, Atlanta, GA 30303-1002, USA
CODEN
EVHPAZ
Publication Date
20101001
Document Type
Journal Article
Email Address
elizabeth.ward@cancer.org
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0091-6765
NIOSH Division
EID; DSHEFS
Priority Area
Agriculture, Forestry and Fishing; Manufacturing
Source Name
Environmental Health Perspectives
State
OH; NC; GA; PA; WA; IA; MD; CA; CT
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