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Microprocessor of microRNAs: regulation and potential for therapeutic intervention.

Authors
Beezhold-KJ; Castranova-V; Chen-F
Source
Mol Cancer 2010 Jun; 9:134
NIOSHTIC No.
20036967
Abstract
MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs.
Keywords
Cell-biology; Cell-division; Cell-function; Cell-transformation; Cellular-function; Cancer; Carcinogenesis
Contact
F. Chen, Ph.D., PPRB/NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
Publication Date
20100601
Document Type
Journal Article
Email Address
LFD3@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISSN
1476-4598
NIOSH Division
HELD
Priority Area
Manufacturing; Mining
Source Name
Molecular Cancer
State
WV
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