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Astrogliosis in CNS pathologies: is there a role for microglia?

Authors
Zhang-D; Hu-X; Qian-L; O'Callaghan-JP; Hong-JS
Source
Mol Neurobiol 2010 Jun; 41(2-3):232-241
NIOSHTIC No.
20036943
Abstract
Astrogliosis, a cellular reaction with specific structural and functional characteristics, represents a remarkably homotypic response of astrocytes to all kinds of central nervous system (CNS) pathologies. Astrocytes play diverse functions in the brain, both harmful and beneficial. Mounting evidence indicates that astrogliosis is an underlying component of a diverse range of diseases and associated neuropathologies. The mechanisms that lead to astrogliosis are not fully understood, nevertheless, damaged neurons have long been reported to induce astrogliosis and astrogliosis has been used as an index for underlying neuronal damage. As the predominant source of proinflammatory factors in the CNS, microglia are readily activated under certain pathological conditions. An increasing body of evidence suggests that release of cytokines and other soluble products by activated microglia can significantly influence the subsequent development of astrogliosis and scar formation in CNS. It is well known that damaged neurons activate microglia very quickly, therefore, it is possible that activated microglia contribute factors/mediators through which damaged neuron induce astrogliosis. The hypothesis that activated microglia initiate and maintain astrogliosis suggests that suppression of microglial overactivation might effectively attenuate reactive astrogliosis. Development of targeted anti-microglial activation therapies might slow or halt the progression of astrogliosis and, therefore, help achieve a more beneficial environment in various CNS pathologies.
Keywords
Biological-effects; Central-nervous-system; Central-nervous-system-disorders; Nervous-system-disorders; Neurological-diseases; Neurological-system; Neuropathology; Neuropathy Neurophysiology; Pathogenicity; Physiological-effects; Physiological-response; Author Keywords: Astrocyte; GFAP; Astrogliosis; Microglia; Cytokine
Contact
Dan Zhang, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
CODEN
MONBEW
Publication Date
20100601
Document Type
Journal Article
Email Address
zhangd2@niehs.nih.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
0893-7648
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Molecular Neurobiology
State
WV
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