Textbook of Clinical Occupational and Environmental Medicine. Rosenstock L, Cullen MR, eds., Philadelphia, PA: W.B. Saunders Company, 1994 Jul; :389-400
Despite the marked decline in developed countries of 40% to 45% in deaths caused by cardiovascular disease. it remains the leading cause of death in the United States. accounting for about 45% of all deaths. About 50% of these deaths are the result of myocardial infarctions. Although identification and modification of cardiovascular risk factors have been areas of intense investigation and effort. the contribution of known major risk factors (advanced age. male gender. hyper· tension. elevated cholesterol level. smoking, physical inactivity, and type II diabetes mellitus) do not explain a significant fraction of the cases of coronary artery disease. Research during the last 40 years has established that a limited number of chemical exposures directly cause or substantially contribute to coronary artery disease. In the last decade, there has been increased interest in the possibility that other aspects of work, such as shift work or work with high demands but in which the worker has little control or influence over how the work is performed. may be additional causal or contributing factors for coronary artery disease (CAD). Particularly for the postulated nonchemical factors. such as shift work or high-demand low-control jobs, the increase in the relative risk for CAD is modest.
Cardiovascular-system-disorders; Cardiovascular-system-disease; Mortality-data; Risk-analysis; Risk-factors; Clinical-techniques; Laboratory-testing; Nitrates; Pathogenesis; Smoking; Shift-work; Hypertension; Cardiac-function; Heart
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Textbook of Clinical Occupational and Environmental Medicine
Despite the marked'decline in developed couOH; DC