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Effects of anticholinergic agents on the intestinal absorption of 59Fe ferrous citrate.

Authors
Orrego-Matte-H; Fernandez-O; Mena-I
Source
Am J Dig Dis 1971 Jan; 16(9):789-795
Link
NIOSHTIC No.
20036917
Abstract
The absorption of 59Fe ferrous citrate has been studied in humans after administration of the anticholinergic agent, hexocyclium methosulfate, and in rats, after atropine. In both species, anticholinergics produced a decrease in absorption. The effect of atropine on iron absorption persisted when the radioiron was delivered intragastrically, mixed with gastric juice, but not when administered intraduodenally. Another set of experiments showed that iron absorption decreases when radioiron is intraduodenally delivered in deproteinized acid gastric juice, or in 0.10 N HCl, but not when mixed with neutralized gastric juice. It is concluded that anticholinergic drugs inhibit iron absorption by an effect on a gastric factor necessary for optimal iron absorption, and not through a decrease in acid secretion.
Keywords
Acids; Biological-effects; Biological-function; Cell-biology; Cellular-reactions; Dietary-effects; Digestive-system; Exposure-assessment; Exposure-levels; Exposure-methods; Gastrointestinal-system; Gastrointestinal-system-disorders; Humans; Iron-compounds; Laboratory-animals; Laboratory-testing; Risk-analysis; Risk-factors; Statistical-analysis
CODEN
AJDDAL
Publication Date
19710101
Document Type
Journal Article
Funding Amount
239133
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00313
Issue of Publication
9
ISSN
0002-9211
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
American Journal of Digestive Diseases
State
DC
Performing Organization
Pan American Health Organization, Washington, Dist of Col
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