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In vivo evaluations of transdermal delivery.

Authors
Guy-R; Hadgraft-J; Hinz-R; Roskos-K; Bucks-D
Source
Transdermal Controlled Systemic Medication. Chien Y, ed., New York: Mercel Dekker, 1987 Jul; :179-224
Link
NIOSHTIC No.
20036912
Abstract
The in vivo evaluation of TDD represents a crucial stage in the development of a therapeutic device. Design of the appropriate test experiment and utilization of a relevant experimental system are of fundamental importance, therefore. The objective of this chapter has been to identify methodologies for assessing TDD in vivo and to elucidate the procedures that may prove most informative and indicative of potential success. There have been useful recent advances in the approaches to measure percutaneous absorption in vivo, and these procedures should be given careful attention when planning for TDD evaluation. The advantages and limitations of various animal models are now more clearly defined and, while there remains no "ideal" system, there is now no excuse for choosing a poorly representative species. Finally, our comprehension of the basic physicochemical and biological criteria, which determine the rate of drug passage across the skin, is becoming more sophisticated. We believe that in the foreseeable future it will be increasingly possible to define chemical structure/skin penetration relationships. Hence, we envisage the achievement of reliable predictions of TDD in vivo, from basic physical chemical and pharmacokinetic information.
Keywords
Pharmaceuticals; Skin-absorption; Pharmacodynamics; Physiological-chemistry; Mathematical-models; Chemical-properties; Physical-properties
Publication Date
19870722
Document Type
Book or book chapter
Editors
Chien-YW
Funding Amount
93049
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
NTIS Price
ISBN No.
9780824777609
Identifying No.
Grant-Number-K01-OH-00017
Source Name
Transdermal Controlled Systemic Medication
State
FL; CA
Performing Organization
University of California San Francisco, San Francisco, California
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