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A mathematical model for predicting the viability of airborne viruses.

Authors
Posada-JA; Redrow-J; Celik-I
Source
J Virol Methods 2010 Mar; 164(1-2):88-95
NIOSHTIC No.
20036901
Abstract
A mathematical model was developed to predict the viability of airborne viruses. The model uses water activity as the primary independent variable and an exponential decay function for the viability of the virus. This model was tested using published experimental data obtained by different investigators for influenza, Langat and polio viruses. The aerosolized media were modelled as a binary solution of water and sodium chloride. The water activity is related directly to the solute concentration in the binary solution. The minimum viability usually occurred just above the efflorescence point, which is the relative humidity at which the solution crystallizes. The relationship between water activity and relative humidity is based on the Köhler theory, whereby the Kelvin term was taken into account. Physical explanations are provided on the variation of viral viability at different relative humidity levels. The predictions obtained by the proposed mathematical model compare well with most of the published experimental data.
Keywords
Airborne-dusts; Airborne-particles; Air-sampling; Biological-agents; Biological-effects; Contagious-diseases; Exposure-assessment; Exposure-levels; Exposure-methods; Health-hazards; Infectious-diseases; Mathematical-models; Quantitative-analysis; Respiratory-infections; Respiratory-system-disorders; Statistical-analysis; Viral-diseases; Viral-infections; Author Keywords: Influenza virus transmission; Mathematical model; Virus viability; Water activity; Airborne virus
Contact
J.A. Posada, Department of Mechanical and Aerospace Engineering, West Virginia University, Engineering Sciences Building, Morgantown, WV 26506-6106
Publication Date
20100301
Document Type
Journal Article
Email Address
alejandro.posada@mail.wvu.edu
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009037
Issue of Publication
1-2
ISSN
0166-0934
Source Name
Journal of Virological Methods
State
WV
Performing Organization
West Virginia University
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