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Disproportionated rosin dehydroabietic acid in neoprene surgical gloves.

Authors
Siegel-PD; Law-BF; Fowler-JF Jr.; Fowler-LM
Source
Dermatitis 2010 May; 21(3):157-159
NIOSHTIC No.
20036899
Abstract
BACKGROUND: Allergic contact dermatitis (ACD) is a well-recognized immune-mediated disease often associated with the use of vulcanization accelerator-containing latex and nitrile gloves. Potential contact allergens in neoprene (polychloroisoprene, polychloroprene) gloves have not been reported. OBJECTIVE: The objective was to analyze extracts of neoprene surgical and examination gloves for potential contact allergens. METHODS: Four different brands of neoprene-type gloves were purchased, and dichloromethane extracts were derivatized and assayed by gas chromatographic mass spectrometry. A latex surgical glove was used as a negative control. RESULTS: Chemical species consistent with the composition of disproportionated rosin (dehydroabietic acid [DHA], didehydroabietic acid, and other pimaric or isopimaric species) were identified in dichloromethane extracts of neoprene gloves. Levels of DHA, a type IV prohapten that can be air oxidized to an active allergen, ranged from 7 to 31 mg/g of glove. A leaching study of DHA was conducted, and small amounts of DHA leached from the glove materials into artificial sweat. DHA oxidation products were not observed in any of the gloves assayed. CONCLUSION: DHA exposure may occur from neoprene-type glove use, although a potential association with glove ACD has not been established.
Keywords
Allergens; Allergic-dermatitis; Allergic-disorders; Allergic-reactions; Allergies; Chromatographic-analysis; Contact-allergies; Contact-dermatitis; Gloves; Immune-reaction; Spectrographic-analysis
Contact
Centers for Disease Control (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV
CAS No.
9010-98-4; 75-09-2
Publication Date
20100501
Document Type
Journal Article
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1710-3568
NIOSH Division
HELD
Source Name
Dermatitis
State
WV
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