Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Relationship between urine bisphenol-A (BPA) level and declining male sexual function.

Authors
Li-D; Zhou-Z; Miao-M; He-Y; Qing-D; Wu-T; Wang-J; Weng-X; Ferber-J; Herrinton-LJ; Zhu-Q; Gao-E; Yuan-W
Source
J Androl 2010 Sep/Oct; 31(5):500-506
NIOSHTIC No.
20036878
Abstract
Background: The adverse effect of Bisphenol-A (BPA) on the male reproductve system observed in animal studies has not been well examined in human populations. BPA is potentially a serious public health problem due to its widely detected presence in the human body. Methods: This study was conducted among 427 male workers in regions where high levels of BPA exposure existed. All participants provided urine samples which were tested for BPA concentration using high performance liquid chromatography. Male sexual dysfunction was ascertained using standard male sexual function inventories. Results: Male sexual dysfunction was measured in four domains using seven indices. After controlling for potential confounders using linear regression, increasing urine BPA level was associated with worsening male sexual function on a continuous scale. All seven indices demonstrated this negative linear correlation. Increasing urine BPA level was associated with decreased sexual desire (p< 0.001), more difficulty having an erection (p<0.001), lower ejaculation strength (p<0.001), and lower level of overall satisfaction with sex life (p<0.01). A similar negative correlation was also observed among participants exposed to BPA from only environmental sources (no occupational exposure to BPA), although the estimates in this group were less stable due to a smaller sample size. Conclusion: Our results reveal a correlation between a biological measure of urine BPA level and declining male sexual function. This finding may enhance the understanding of the BPA effect in human populations and have important public health implications given the widespread human exposure to BPA. Summary: A high urine BPA level is associated with an increased risk of male sexual dysfunction, demonstrating a dose-response relationship. This finding provides new evidence of BPA effects on the male reproductive system in humans.
Keywords
Reproductive-system-disorders; Sexual-reproduction; Men; Endocrine-function; Epidemiology; Phenols; Occupational-exposure; Urinalysis; Plastic-products; Plastics-industry; Polychlorinated-biphenyls; Epoxy-resins; Author Keywords: BPA; Bisphenol-A; Epidemiology; Cohort-study; Male-reproductive-system; Sexual-dysfunction
Contact
De-Kun Li, MD, PhD, Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
CODEN
JOAND3
CAS No.
80-05-7
Publication Date
20100901
Document Type
Journal Article
Email Address
dkl@dor.kaiser.org
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007580
Issue of Publication
5
ISSN
0196-3635
Source Name
Journal of Andrology
State
CA
Performing Organization
Kaiser Foundation Research Institute
TOP