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Frequency dependent effects of vibration on nerve function, oxidative stress and inflammation.

Authors
Pacurari-M; Johnson-C; Krajnak-K
Source
FASEB J 2010 Apr; 24(Meeting Abstracts):1054.2
NIOSHTIC No.
20036783
Abstract
Prolonged occupational exposure to hand-held vibrating tools leads to pain and reductions in tactile sensitivity, grip strength and manual dexterity. The goal of the current study was to use a rat-tail model to determine if vibration frequency influences factors related to sensorineural dysfunction. We tested the hypothesis that exposure to tail vibration (4 hr/day for 3 days) at a high frequency (250 Hz) would result in sensorineural dysfunction and greater increases in oxidative stress and inflammation in tail nerves than exposure to vibration at a lower frequency (62.5 Hz). Nerve function was assessed using transcutaneous electrical stimulation. Exposure to 250-Hz, but not 62.5-Hz vibration, resulted in an increased sensitivity of A- and A-nerve fibers to electrical stimulation. These changes in nerve fiber sensitivity were associated with increased expression of interleukin (IL)-1 and tumor necrosis factor - in tail nerves, and a moderate increase in cyclooxygenase-2 gene expression. Circulating concentrations of IL-1 were also increased. Vibration exposure at both frequencies resulted in reductions in glutathione and glutathione peroxidase 3 levels in tail nerves. However gene expression for other oxidative factors and nitrotyrosine protein levels were significantly increased after exposure to vibration at 62.5 Hz, but not 250 Hz. These results demonstrate that the effects of vibration on sensorineural function and physiology are frequency dependent, and that changes in nerve function may be related to increases in inflammation and oxidative activity.
Keywords
Exposure-assessment; Exposure-levels; Exposure-methods; Hand-tools; Laboratory-testing; Nerve-function; Nerves; Neurological-diseases; Neurological-reactions; Neuromotor-disorders; Neuromotor-system; Neuromotor-system-disorders; Occupational-diseases; Occupational-exposure; Occupational-hazards; Oxidative-metabolism; Oxidative-processes; Sensitivity-testing; Sensory-disorders; Sensory-motor-system; Vibration-disease; Vibration-effects; Vibration-exposure
CODEN
FAJOEC
Publication Date
20100401
Document Type
Abstract
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
Abstracts
ISSN
0892-6638
NIOSH Division
HELD
Source Name
The FASEB Journal. Experimental Biology 2010, April 24 - 28, 2010, Anaheim, California
State
WV; CA
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