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Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves.

Authors
Que-Hee-SS; Zainal-H
Source
Arch Environ Contam Toxicol 2010 Feb; 58(2):249-254
NIOSHTIC No.
20036751
Abstract
The aim of this study was to measure permeation of the herbicide dichlobenil in Casoron 4G through disposable and chemically protective nitrile gloves using an American Society for Testing and Materials-type permeation cell and a closed-loop system employing two different solvents (hexane and water) and two different challenge situations (aqueous emulsion and solid formulation). Capillary gas chromatography-mass spectrometry was used for quantification purposes. The chemically protective glove did not allow any permeation up to 8 h for the solid-formulation and water-collection challenges, but permeation was detected in all other challenges. The disposable glove allowed the most permeation, and the solid-formulation challenge with water collection necessitated that a dichlobenil equivalent be calculated because of the presence of its hydrolysis degradation product 2,6-dichlorobenzamide. Permeation from the solid formulation was detectable by hexane collection for both the disposable and chemically protective gloves and by water collection for the disposable glove. It was concluded that hexane-solvent collection was not valid for the disposable glove at 4 and 8 h of permeation in the solid Casoron challenge or for the aqueous emulsion challenge at 8 h relative to the water-collection solvent data. The hexane-solvent collection for the chemically protective glove was valid for the 8-h solid-formulation challenge but not for the 8-h aqueous-solution challenge. All water-solvent collections were valid; however, dichlobenil usually permeated the gloves.
Keywords
Biochemical-analysis; Chemical-properties; Chemical-synthesis; Exposure-assessment; Exposure-levels; Exposure-methods; Gloves; Herbicides; Mathematical-models; Personal-protection; Protective-materials; Protective-measures
Contact
Shane S. Que Hee, Department of Environmental Health Sciences and UCLA Center for Occupational and Environmental Health, School of Public Health, University of California at Los Angeles, 650 Charles Young Jr Drive South, Los Angeles, CA 90095-1772
CODEN
AECTCV
CAS No.
1194-65-6
Publication Date
20100201
Document Type
Journal Article
Email Address
squehee@ucla.edu
Funding Amount
705469
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003754
Issue of Publication
2
ISSN
0090-4341
Source Name
Archives of Environmental Contamination and Toxicology
State
CA
Performing Organization
University of California Los Angeles
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