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Genetic polymorphisms in metabolizing enzymes and susceptibility of chromosomal damage induced by vinyl chloride monomer in a Chinese worker population.

Authors
Wang-W; Qiu-YL; Ji-F; Liu-J; Wu-F; Miao-WB; Li-Y; Brandt-Rauf-PW; Xia-ZL
Source
J Occup Environ Med 2010 Feb; 52(2):163-168
NIOSHTIC No.
20036740
Abstract
OBJECTIVE: To evaluate whether polymorphisms in metabolizing enzymes contributed to susceptibility of chromosomal damage induced by vinyl chloride monomer (VCM). METHODS: Cytokinesis block micronucleus test was performed on 185 VCM-exposed workers and 41 control subjects to detect chromosomal damage in peripheral lymphocytes. The polymerase chain reaction and restriction fragment length polymorphism technique was applied to detect polymorphisms of GSTT1, GSTM1, GSTP1G/A, CYP2E1G/C, and CYP2D6G/C. Poisson regression analysis was performed. RESULTS: Sex, age, VCM exposure, GSTP1, and CYP2E1 genotype can influence chromosomal damage. There was a 1.51-fold increased micronucleus frequency for GSTP1GG genotypes individuals compared with those GSTP1AA/GA genotype individuals (P < 0.05), the effect of polymorphism in CYP2E1 gene was more pronounced for allele C compared with allele G (P < 0.05). CONCLUSIONS: Polymorphisms of GSTP1G/A and CYP2E1G/C, which are potential susceptibility biomarkers of chromosomal damage in VCM-exposed worker.
Keywords
Biological-effects; Biological-factors; Biomarkers; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Genetic-factors; Genotoxicity; Mutagenesis; Mutagens; Risk-analysis
Contact
Dr. Zhaolin Xia, MD, PhD, Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
CODEN
JOEMFM
Publication Date
20100201
Document Type
Journal Article
Email Address
zlxia@shmu.edu.cn
Funding Amount
163500
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004192
Issue of Publication
2
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
IL
Performing Organization
University of Illinois
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