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Intrauterine tobacco exposure may alter auditory brainstem responses in newborns.

Authors
Peck-JD; Neas-B; Robledo-C; Saffer-E; Beebe-L; Wild-RA
Source
Acta Obstet Gynecol Scand 2010 Apr; 89(4):592-596
NIOSHTIC No.
20036700
Abstract
This study of tobacco exposure and auditory processes was conducted in a predominantly low-income population of 40 pregnant women and their newborns. Urinary cotinine concentrations and self-reported smoking status were obtained from the mother during the first prenatal care visit. Auditory brainstem-evoked responses (ABRs) were recorded in neonates to assess neuroelectrical activity of the auditory nerve following a sound stimulus. Infants of mothers with the highest cotinine concentrations (> 1,000 ng/ml) responded at a rate that was four times greater (hazard ratio 4.1, 95% confidence interval 1.4-11.5) than infants of non-smoking mothers (cotinine 15-1,000 ng/ml) were not observed. Enhanced ABRs may disrupt auditory processes related to speech perception, negatively affecting reading and language development during childhood. The results suggest that tobacco exposure during pregnancy may impair auditory function.
Keywords
Auditory-system; Biological-effects; Exposure-assessment Exposure-levels; Exposure-methods; Neurological-reactions; Prenatal-exposure; Risk-analysis; Statistical-analysis; Tobacco-constituents; Author Keywords: Tobacco; smoking; cotinine; auditory brainstem response; newborn
Contact
Jennifer David Peck, Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104
CODEN
AOGSAE
Publication Date
20100401
Document Type
Journal Article
Email Address
jennifer-peck@ouhsc.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008421
Issue of Publication
4
ISSN
0001-6349
Source Name
Acta Obstetricia et Gynecologica Scandinavica
State
TX; OK
Performing Organization
University of Texas, Health Science Center, Houston, Texas
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