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Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability.

Authors
Qian-Y; Ducatman-A; Ward-R; Leonard-S; Bukowski-V; Lan Guo-N; Shi-X; Vallyathan-V; Castranova-V
Source
J Toxicol Environ Health, A 73(12):819-836
NIOSHTIC No.
20036673
Abstract
Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment. In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level.
Keywords
Organic-chemicals; Organic-compounds; Cell-damage; Cellular-reactions; Antioxidants
Contact
Yong Qian, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
CODEN
JTEHD6
Publication Date
20100101
Document Type
Journal Article
Email Address
yaq2@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1528-7394
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV; KY
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