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DOD impact assessment and management of naphthalene-related risks.

Authors
Hulla-J; Snawder-JE; Proctor-SP; Chapman-GD
Source
Toxicologist 2010 Mar; 114(1):400
NIOSHTIC No.
20036671
Abstract
The Department of Defense Chemical and Materials Risk Management Directorate is using a scan-watch-action process to identify, rank and manage risks associated with emerging contaminants. Naphthalene is characterized as a likely human carcinogen by the NTP and in the EPA's most recent draft health risk assessment. Thus, naphthalene-related environmental health regulations are evolving. The potential impacts have been assessed, using multi-criteria decision analysis, for five of the Department's functional areas. One of the areas of concern is exposure to naphthalene among fuel handlers. To determine whether these exposures present unacceptable risk, the Army Research Office awarded a Small Business Innovative Research Project for the development of a miniature real-time naphthalene sensor. NIOSH's Biomoniting Team and Investigators from the Army Research Institute for Environmental Medicine, UC-Davis and the Army Corps of Engineers are collaborating on a second DOD-funded project. This project will validate the prototype sensor as a dosimeter by defining correlations between measured exposures and biomarkers of exposures to-be-collected from military fuel handlers. To date, naphthalene specificity with sensitivity of 0.5 mg/m3 has been demonstrated and definition of the firmware chemometrics is underway. Implementation of the human subjects research protocol is pending institutional review boards' approval.
Keywords
Biochemical-analysis; Biochemical-indicators; Biohazards; Biological-effects; Biomarkers; Chemical-hypersensitivity; Chemical-indicators; Chemical-properties; Chemical-reactions; Exposure-assessment; Exposure-levels; Exposure-methods; Physiological-response; Quantitative-analysis; Statistical-analysis
CAS No.
91-20-3
Publication Date
20100301
Document Type
Abstract
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
DART
Source Name
The Toxicologist. Society of Toxicology 49th Annual Meeting and ToxExpo, March 7-11, 2010, Salt Lake City, Utah
State
UT; CA; MD; OH
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