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Persistent organochlorine pesticides in serum and risk of Parkinson disease.

Authors
Weisskopf-MG; Knekt-P; O'Reilly-EJ; Lyytinen-J; Reunanen-A; Laden-F; Altshul-L; Ascherio-A
Source
Neurology 2010 Mar; 74(13):1055-1061
NIOSHTIC No.
20036654
Abstract
Background: Pesticides have been implicated as likely environmental risk factors for Parkinson disease (PD), but assessment of past exposure to pesticides can be difficult. No prior studies of pesticide exposure and PD used biomarkers of exposure collected before the onset of PD. Our investigation examined the association between prospective serum biomarkers of organochlorine pesticides and PD. Methods: We conducted a nested case-control study within the Finnish Mobile Clinic Health Examination Survey, with serum samples collected during 1968-1972, and analyzed in 2005-2007 for organochlorine pesticides. Incident PD cases were identified through the Social Insurance Institution's nationwide registry and were confirmed by review of medical records (n = 101). Controls (n = 349) were matched for age, sex, municipality, and vital status. Adjusted odds ratios (ORs) of PD were estimated using logistic regression. Results: Little association emerged with a summary score of the 5 organochlorine pesticides found at high levels, and only increasing dieldrin concentrations trended toward a higher risk of PD (OR per interquartile range [IQR] 1.28, 95% confidence interval [CI] 0.97-1.69, p = 0.08). Because of possible strong confounding by cigarette smoking among smokers, we ran additional analyses restricted to never smokers (n = 68 cases, 183 controls). In these analyses, increasing dieldrin concentrations were associated with increased odds of PD (OR per IQR 1.95, 95% CI 1.26-3.02, p = 0.003). None of the other organochlorine pesticides were associated with PD in these analyses. Conclusions: These results provide some support for an increased risk of Parkinson disease with exposure to dieldrin, but chance or exposure correlation with other less persistent pesticides could contribute to our findings.
Keywords
Analytical-methods; Analytical-processes; Biohazards; Biological-effects; Biological-systems; Biomarkers; Exposure-assessment; Exposure-levels Exposure-methods; Neurological-diseases; Neurological-reactions; Neurological-system; Neuropathy; Organic-chemicals; Pesticide-residues; Pesticides-and-agricultural-chemicals; Risk-analysis; Statistical-analysis
Contact
Dr. Marc G. Weisskopf, Harvard School of Public Health, Department of Environmental Health, Landmark Center, Third Floor East, PO Box 15697, Boston, MA 02215
CODEN
NEURAI
Publication Date
20100330
Document Type
Journal Article
Email Address
mweissko@hsph.harvard.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008171; Grant-Number-R01-OH-008649
Issue of Publication
13
ISSN
0028-387
Source Name
Neurology
State
MA
Performing Organization
Brigham and Women's Hospital
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