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Vibration-induced changes in oxidative stress and expression of inflammatory factors are frequency dependent.

Authors
Krajnak-K; Waugh-S; Miller-R; Johnson-C; Kashon-M
Source
FASEB J 2009 Apr; 23(Meeting Abstracts):592.1
NIOSHTIC No.
20036642
Abstract
Repetitive exposure to vibration through the use of powered hand tools is associated with the development of vibration white finger (VWF), a disorder that is characterized by cold-induced vasospasms that result in blanching of the skin. The risk of developing VWF appears to be dependent upon the frequency of the exposure. The goal of this study was to assess frequency dependent changes in gene expression and oxidative stress in a rat-tail model of VWF. Rats (n = 5/group) were exposed to vibration (63, 125, or 250 Hz) or control conditions for 4 h/day for 10 days. After the last exposure, gene expression and oxidative stress were assessed in ventral tail arteries. Transcript levels of pro-inflammatory factors were increased in arteries of rats exposed to 63 Hz vibration compared to controls. In contrast, oxidative stress (e.g., peroxynitrite) was higher in rats exposed to 125 and 250 Hz vibration. These results demonstrate that the biological responses of peripheral arteries to vibration are frequency dependent. The frequency dependent differences in these responses may affect the risk of developing vibration-induced vascular dysfunction.
Keywords
Animal-studies; Exposure-assessment; Exposure-levels; Exposure-methods; Hand-tools; Laboratory-animals; Laboratory-testing; Oxidation; Repetitive-work; Statistical-analysis; Tools; Vibration-effects; Vibration-exposure
CODEN
FAJOEC
Publication Date
20090401
Document Type
Abstract
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
Abstracts
ISSN
0892-6638
NIOSH Division
HELD
Source Name
The FASEB Journal. Experimental Biology 2009, April 18 - 22, 2009, New Orleans, Louisiana
State
WV; LA
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