Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Predicting skin permeability: incorporation of chemical mixture effects into simple quantitative structure permeation relationships (QSPER).

Authors
Riviere-JE; Brooks-JD
Source
Toxicologist 2010 Mar; 114(1):107
NIOSHTIC No.
20036607
Abstract
Predicting the degree of dermal absorption of topically exposed chemicals is an important issue in both environmental and occupational risk assessment. Most risk assessment approaches and QSPeR models are based on data obtained from dosing chemicals neat or in simple aqueous vehicles, yet most exposures are to complex mixtures. We have previously demonstrated that a simple QSPeR model based on 12 penetrants in 24 mixtures could be constructed if the physical chemical properties of the mixture components and vehicle were also incorporated. The present study significantly expands on this analysis by increasing the number of penetrants studied using in vitro porcine skin diffusion cells to 16 for a total of 384 treatment combinations. In addition, we applied the model to 31 penetrants dosed in a total of 189 treatment combinations using an isolated perfused porcine skin model previously shown to be predictive of in vivo human absorption. These studies demonstrated that mixture chemical descriptors including topical polar surface area/or ovality significantly improve prediction of dermal absorption using different base QSPeR models (e.g. Abraham 5-term or Potts and Guy 2-term models). These studies suggest that such information could be incorporated into dermal risk assessment protocols to improve prediction of chemical absorption based on more realistic exposure scenarios.
Keywords
Biological-effects; Cellular-reactions; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Environmental-exposure; Exposure-assessment; Exposure-levels; Exposure-methods; Laboratory-testing; Occupational-exposure; Risk-analysis; Risk-factors; Skin; Skin-exposure; Skin-irritants; Skin-sensitivity; Statistical-analysis; Toxic-effects
Publication Date
20100301
Document Type
Abstract
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007555
Issue of Publication
1
ISSN
1096-6080
Priority Area
Work Environment and Workforce: Mixed Exposures
Source Name
The Toxicologist. Society of Toxicology 49th Annual Meeting and ToxExpo, March 7-11, 2010, Salt Lake City, Utah
State
WV; UT; NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
TOP