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Pulmonary alveolar proteinosis in workers at an indium processing facility.

Authors
Cummings-KJ; Donat-WE; Ettensohn-DB; Roggli-VL; Ingram-P; Kreiss-K
Source
Am J Respir Crit Care Med 2010 Mar; 181(5):458-464
NIOSHTIC No.
20036549
Abstract
Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism.
Keywords
Airborne-dusts; Alveolar-cells; Chemical-industry-workers; Dust-inhalation; Dust-particles; Dusts; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Inhalation-studies; Occupational-exposure; Occupational-hazards; Occupational-health; Particulate-dust; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Respiratory-hypersensitivity; Respiratory-irritants; Respiratory-system-disorders; Statistical-analysis; Author Keywords: pulmonary alveolar proteinosis; indium
Contact
Kristin J. Cummings, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, MS 2800, Morgantown, WV 26505
CODEN
AJCMED
Publication Date
20100301
Document Type
Journal Article
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1073-449X
NIOSH Division
DRDS
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV; RI; NC
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