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Transcriptional responses to oxidative stress: pathological and toxicological implications.

Authors
Ma-Q
Source
Pharmacol Ther 2010 Mar; 125(3):376-393
NIOSHTIC No.
20036497
Abstract
The utilization of molecular oxygen as the terminal electron acceptor for energy production has in many ways shaped the evolution of complex life, physiology, and certain disease processes. The generation of reactive oxygen species (ROS), either as by-products of O2 metabolism or by specialized enzymes, has the potential to damage cellular components and functions. Exposure to a variety of exogenous toxicants also promotes ROS production directly or through indirect means to cause toxicity. Oxidative stress activates the expression of a wide range of genes that mediate the pathogenic effect of ROS or are required for the detection and detoxification of the oxidants. In many cases, these are mediated by specific transcription factors whose expression, structure, stability, nuclear targeting, or DNA-binding affinity is regulated by the level of oxidative stress. This review examines major transcription factors that mediate transcriptional responses to oxidative stress, focusing on recent progress in the signaling pathways and mechanisms of activation of transcription factors by oxidative stress and the implications of this regulation in the development of disease and chemical toxicity.
Keywords
Genes; Genetics; Genotoxic-effects; Stress; Author Keywords: Reactive oxygen species; Oxidative stress; Transcription factor; Gene regulation; Disease; Chemical toxicity
Contact
Qiang Ma, Mailstop 3014, 1095 Willowdale Rd., Morgantown, WV 26505, United States
CODEN
PHTHDT
Publication Date
20100301
Document Type
Journal Article
Email Address
qam1@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0163-7258
NIOSH Division
HELD
Source Name
Pharmacology & Therapeutics
State
WV
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