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Distribution of airborne influenza virus and respiratory syncytial virus in an urgent care medical clinic.

Authors
Lindsley-WG; Blachere-FM; Davis-KA; Pearce-TA; Fisher-MA; Khakoo-R; Davis-SM; Rogers-ME; Thewlis-RE; Posada-JA; Redrow-JB; Celik-IB; Chen-BT; Beezhold-DH
Source
Clin Infect Dis 2010 Mar; 50(5):693-698
NIOSHTIC No.
20036488
Abstract
Background. Considerable controversy exists with regard to whether influenza virus and respiratory syncytial virus (RSV) are spread by the inhalation of infectious airborne particles and about the importance of this route, compared with droplet or contact transmission. Methods. Airborne particles were collected in an urgent care clinic with use of stationary and personal aerosol samplers. The amounts of airborne influenza A, influenza B, and RSV RNA were determined using real-time quantitative polymerase chain reaction. Health care workers and patients participating in the study were tested for influenza. Results. Seventeen percent of the stationary samplers contained influenza A RNA, 1% contained influenza B RNA, and 32% contained RSV RNA. Nineteen percent of the personal samplers contained influenza A RNA, none contained influenza B RNA, and 38% contained RSV RNA. The number of samplers containing influenza RNA correlated well with the number and location of patients with influenza (r = 0.77). Forty-two percent of the influenza A RNA was in particles <= 4.1 mu m in aerodynamic diameter, and 9% of the RSV RNA was in particles <= 4.1 mu m. Conclusions. Airborne particles containing influenza and RSV RNA were detected throughout a health care facility. The particles were small enough to remain airborne for an extended time and to be inhaled deeply into the respiratory tract. These results support the possibility that influenza and RSV can be transmitted by the airborne route and suggest that further investigation of the potential of these particles to transmit infection is warranted.
Keywords
Airborne-dusts; Airborne-particles; Air-sampling; Biological-agents; Biological-effects; Biological-transport; Contagious-diseases; Exposure-assessment; Exposure-levels; Exposure-methods; Health-care-facilities; Health-hazards; Immune-system-disorders; Infectious-diseases; Quantitative-analysis; Respiratory-infections; Respiratory-system-disorders; Statistical-analysis; Viral-diseases; Viral-infections
Contact
William G. Lindsley, West Virginia University, NIOSH, CDC, HELD, 1095 Willowdale Rd,M-S 2015, Morgantown, WV 26505
CODEN
CIDIEL
Publication Date
20100301
Document Type
Journal Article
Email Address
wlindsley@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009037
Issue of Publication
5
ISSN
1058-4838
NIOSH Division
HELD
Source Name
Clinical Infectious Diseases
State
WV
Performing Organization
West Virginia University
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