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Oxidative stress, pulmonary toxicity of single walled carbon nanotubes in vivo: relevance to occupational exposures.

Authors
Shvedova-AA
Source
International Conference on Advances in Free Radicals Research, Natural Products, Antioxidants and Radioprotectors in Health & Ninth Annual Meeting of the Society of Free Radical Research - India, January 11 - 13, 2010, Hyderabad, Andhra Pradesh India. Hyderabad, Andhra Pradesh: India, Nizam's Institute of Medical Sciences, 2010 Jan; :38-39
Link
NIOSHTIC No.
20036470
Abstract
Single-Walled Carbon Nanotubes (SWCNT) are new materials of emerging technological importance and have unique physico-chemical, electronic and mechanical properties. Therefore, they may exhibit unusual interactions with cells and tissues, thus necessitating studies of their toxicity and health effects. We have demonstrated that SWCNT in doses relevant to potential occupational exposures may exert toxic effects in the lung of exposed animals in vivo. We have characterized an unusual and robust inflammatory and fibrogenic response and correlated it with the progression of oxidative stress. We also established that SWCNT induced inflammation and exposure caused altered pulmonary function. Because realistic exposures, to SWCNT are likely to occur in conjunction with other pathogenic impacts, e.g., microbial infections, our findings that bacterial clearance from the lungs of SWCNT exposed mice was compromised is of great importance. This talk will address important issues of respiratory toxicity of SWCNT causing substantial pulmonary injury; including fibrosis; results also provide clues elucidation toward underlying mechanisms of toxicity.
Keywords
Toxicopathology; Toxic-effects; Respiratory-system-disorders; Respiratory-infections; Fibrosis; Fibrogenicity; Fibrogenesis; Pulmonary-system-disorders; Nanotechnology
CAS No.
7440-44-0
Publication Date
20100111
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
ats1@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
NIOSH Division
HELD
Source Name
International Conference on Advances in Free Radicals Research, Natural Products, Antioxidants and Radioprotectors in Health & Ninth Annual Meeting of the Society of Free Radical Research - India
State
WV
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