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Development of a sampler for total aerosol deposition in the human respiratory tract.

Authors
Koehler-KA; Clark-P; Volckens-J
Source
Ann Occup Hyg 2009 Oct; 53(7):731-738
NIOSHTIC No.
20036436
Abstract
Studies that seek to associate reduced human health with exposure to occupational and environmental aerosols are often hampered by limitations in the exposure assessment process. One limitation involves the measured exposure metric itself. Current methods for personal exposure assessment are designed to estimate the aspiration of aerosol into the human body. Since a large proportion of inhaled aerosol is subsequently exhaled, a portion of the aspirated aerosol will not contribute to the dose. This leads to variable exposure misclassification (for heterogenous exposures) and increased uncertainty in health effect associations. Alternatively, a metric for respiratory deposition would provide a more physiologically relevant estimate of risk. To address this challenge, we have developed a method to estimate the deposition of aerosol in the human respiratory tract using a sampler engineered from polyurethane foam. Using a semi-empirical model based on inertial, gravitational, and diffusional particle deposition, a foam was engineered to mimic aerosol total deposition in the human respiratory tract. The sampler is comprised of commercially available foam with fiber diameter = 49.5 microm (equivalent to industry standard 100 PPI foam) of 8 cm thickness operating at a face velocity of 1.3 m s(-1). Additionally, the foam sampler yields a relatively low-pressure drop, independent of aerosol loading, providing uniform particle collection efficiency over time.
Keywords
Aerosols; Exposure-assessment; Exposure-levels; Exposure-methods; Inhalation-studies; Particle-aerodynamics; Particle-counters; Respiratory-irritants; Respiratory-system-disorders; Samplers; Sampling; Author Keywords: aerosols; exposure estimation; gravimetric analysis
Contact
John Volckens, Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO 80523
CODEN
AOHYA3
Publication Date
20091001
Document Type
Journal Article
Email Address
john.volckens@colostate.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-009248
Issue of Publication
7
ISSN
0003-4878
Source Name
Annals of Occupational Hygiene
State
CO
Performing Organization
Colorado State University - Fort Collins
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