Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Immunotoxicology.

Authors
Luebke-RW; Beamer-CA; Bowman-C; DeWitt-J; Gowdy-K; Johnson-VJ; Shepherd-DM; Germolec-DR
Source
General and Applied Toxicology, 3rd Edition, Volume 1. Ballantyne B, Marrs TC, Syversen TLM, eds., Chichester, West Sussex, U.K.: John Wiley & Sons, 2009 Dec; 1:64.1-64.23
Link
NIOSHTIC No.
20036420
Abstract
For the purposes of risk assessment, immunotoxicity is defined as unintended modulation of immune function. Depending on dose, duration of exposure, mode of action and biopersistence, immune system effects may be detectable at the molecular or cellular level (altered markers of exposure) and/or at the organism level (altered function, adverse health effects). As depicted in Figure 1, suppression of immune function is associated with increased rates of infection and some types of cancer, whereas inappropriate modulation of the immune system may result in allergic and autoimmune responses.
Keywords
Risk-factors; Risk-analysis; Immune-reaction; Immunology; Immunotoxins; Dose-response; Dosimetry
Publication Date
20091230
Document Type
Book or book chapter
Editors
Ballantyne-B; Marrs-TC; Syversen-TLM
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISBN No.
9780470723272
NIOSH Division
HELD
Priority Area
Services
Source Name
General and Applied Toxicology, Volume 2
State
WV
TOP