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Latex as a significant source of Hevea brasiliensis allergen exposure.

Authors
Kostyal-D; Horton-K; Beezhold-D; Lockwood-S; Hamilton-RG
Source
Ann Allergy, Asthma, & Immun 2009 Oct; 103(4):354-355
NIOSHTIC No.
20036412
Abstract
The prevalence of allergic reactions to Hevea brasiliensis natural rubber latex among high-risk health care workers and patients undergoing multiple surgical procedures has diminished from epidemic levels in the mid-1990s. This decrease is attributed to avoidance of powdered latex medical gloves and improved quality control in the manufacturing process. However, sensitization to Hevea allergens continues through exposure to less well established sources. To document this phenomenon, we used 3 standardized methods approved by the American Society for Testing Materials (ASTM) to quantify the total protein (ASTM Standard Test Method for Analysis of Aqueous Extractable Protein in Natural Rubber and Its Products Using the Modified Lowry Method, 2005), Hevea antigen (ASTM Standard Test Method for the Immunological Measurement of Antigenic Protein in Natural Rubber and Its Products, 2007), and Hevea allergen (ASTM Standard Test Method for Immunological Measurement of Four Principal Allergenic Proteins in Natural Rubber and Its Products Derived From Latex, 2008 content in natural rubber latex toy balloons, dental dams, medical gloves, and nitrile and guayule medical gloves (negative controls). Although previous studies examined allergen/antigen content in rubber medical products, this study simultaneously investigated Hevea levels in balloons, dental dams, and glove products using the 3-tier ASTM test protocol.
Keywords
Allergens; Allergic-disorders; Allergic-reactions; Allergies; Exposure-assessment; Exposure-levels; Exposure-methods; Health-care-personnel; Occupational-hazards; Occupational-health; Quantitative-analysis Risk-analysis; Risk-factors; Statistical-analysis; Work-analysis; Work-environment; Work-operations; Workplace-studies; Work-practices
CODEN
ALAIF6
Publication Date
20091001
Document Type
Other
Email Address
kostyal_david@guthrie.org
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1081-1206
NIOSH Division
HELD
Source Name
Annals of Allergy, Asthma, and Immunology
State
WV; MD; PA
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