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Oral contraceptives: a risk factor for squamous cell carcinoma?

Authors
Applebaum-KM; Nelson-HH; Zens-MS; Stukel-TA; Spencer-SK; Karagas-MR
Source
J Invest Dermatol 2009 Dec; 129(12):2760-2765
NIOSHTIC No.
20036288
Abstract
Oral contraceptives (OCs) affect the risk of several cancers in women, but have been virtually unstudied for squamous cell carcinoma (SCC). We examined the hypothesis that OCs influence SCC risk in a case-control study among women and also examined whether polymorphisms in the DNA repair gene, Xeroderma pigmentosum group D (XPD), modified the risk. Incident cases of SCC were identified by a network of dermatologists and pathology laboratories. Population-based controls were frequency matched to cases by age and gender (n=261 SCC cases, 298 controls). Overall, OC use was associated with a 60% higher risk of SCC (odds ratio (OR), 1.6; 95% confidence interval (95% CI): 1.0-2.5). ORs for SCC were higher among those who last used OCs > or =25 years before diagnosis (OR: 2.1; 95% CI: 1.2-3.7), and among these women, SCC risk increased with duration of use (OR for < or =2 years, 1.7; 95% CI: 0.9-3.5; OR for 3-6 years, 2.6; 95% CI: 1.0-6.5; OR for > or =7 years, 2.7; 95% CI: 0.9-8.5, P(trend)=0.01). Furthermore, the XPD Lys751Gln polymorphism was a significant modifier of the OC-SCC association (P(interaction)=0.03). These findings lead us to hypothesize a potential relationship between OCs and SCC risk, and that this could involve DNA repair pathways.
Keywords
Age-factors; Cancer-rates; Carcinogenicity; Carcinogens; Cell-biology; Cell-damage; Cell-morphology; Cellular-reactions; Reproductive-hazards; Risk-analysis; Sex-factors; Skin; Skin-cancer; Skin-disorders; Statistical-analysis
Contact
Dr Margaret R Karagas, Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, 1 Medical Center Drive, 7927 Rubin Building, Lebanon, New Hampshire 03756
CODEN
JIDEAE
Publication Date
20091201
Document Type
Journal Article
Email Address
Margaret.R.Karagas@Dartmouth.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009390
Issue of Publication
12
ISSN
0022-202X
Priority Area
Manufacturing
Source Name
Journal of Investigative Dermatology
State
MA; NH
Performing Organization
Boston University Medical Campus
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