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Evaluation of local MCP-1 and IL-12 nanocoatings for infection prevention in open fractures.

Authors
Li-B; Jiang-B; Dietz-MJ; Smith-ES; Clovis-NB; Rao-KM
Source
J Orthop Res 2010 Jan; 28(1):48-54
NIOSHTIC No.
20036259
Abstract
The increasing incidence of bacterial infection and the appearance of Staphylococcus aureus (S. aureus) strains that are resistant to commonly used antibiotics has made it important to develop non-antibiotic approaches for infection prevention. The aim of this study was to develop local monocyte chemoattractant protein-1 (MCP-1) and interleukin-12 p70 (IL-12 p70) therapies to prevent S. aureus infection by enhancing the recruitment and activation of macrophages, which are believed to play an important role in infection prevention as the first line of defense against invading pathogens. Nanocoating systems for MCP-1 and IL-12 p70 deliveries were prepared, and their release characteristics desirable for infection prevention in open fractures were explored. Local MCP-1 therapy reduced S. aureus infection and influenced white blood cell populations, and local IL-12 p70 treatment had a more profound effect on preventing S. aureus infection. No synergistic relationship in decreasing S. aureus infection was observed when MCP-1 and IL-12 p70 treatments were combined. This reported new approach may reduce antibiotic use and antibiotic resistance.
Keywords
Infection-control; Infectious-diseases; Bacterial-disease; Bacterial-infections; Author Keywords: infection; trauma; cell-mediated immunity; antibiotic resistance; local drug delivery
Contact
Bingyun Li, Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506
CODEN
JOREDR
Publication Date
20100101
Document Type
Journal Article
Email Address
bli@hsc.wvu.edu
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0736-0266
NIOSH Division
HELD
Source Name
Journal of Orthopaedic Research
State
WV
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