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Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.

Authors
Hoppin-JA; Umbach-DM; London-SJ; Henneberger-PK; Kullman-GJ; Coble-J; Alavanja-MC; Beane Freeman-LE; Sandler-DP
Source
Eur Respir J 2009 Dec; 34(6):1296-1303
NIOSHTIC No.
20036203
Abstract
Although specific pesticides have been associated with wheeze in farmers, little is known about pesticides and asthma. Data from 19,704 male farmers in the Agricultural Health Study were used to evaluate lifetime use of 48 pesticides and prevalent adult-onset asthma, defined as doctor-diagnosed asthma after the age of 20 yrs. Asthma cases were categorised as allergic (n = 127) and nonallergic (n = 314) based on their history of eczema or hay fever. Polytomous logistic regression, controlling for age, state, smoking and body mass, was used to assess pesticide associations. High pesticide exposure events were associated with a doubling of both allergic and nonallergic asthma. For ever-use, 12 individual pesticides were associated with allergic asthma and four with nonallergic asthma. For allergic asthma, coumaphos (OR 2.34; 95% CI 1.49-3.70), heptachlor (OR 2.01; 95% CI 1.30-3.11), parathion (OR 2.05; 95% CI 1.21-3.46), 80/20 mix (carbon tetrachloride/carbon disulfide) (OR 2.15; 95% CI 1.23-3.76) and ethylene dibromide (OR 2.07; 95% CI 1.02-4.20) all showed ORs of >2.0 and significant exposure-response trends. For nonallergic asthma, DDT (dichlorodiphenyltrichloroethane) showed the strongest association (OR 1.41; 95% CI 1.09-1.84), but with little evidence of increasing asthma with increasing use. Current animal handling and farm activities did not confound these results. There was little evidence that allergy alone was driving these associations. In conclusion, pesticides may be an overlooked contributor to asthma risk among farmers.
Keywords
Agricultural-workers; Agriculture; Agricultural-industry; Respiratory-system-disorders; Pulmonary-system-disorders; Bronchial-asthma; Respiratory-irritants; Pesticides; Pesticides-and-agricultural-chemicals; Insecticides; Men; Epidemiology; Statistical-analysis; Allergens; Allergic-reactions; Allergies; Farmers; Author Keywords: Allergy; farming; occupational exposure; pesticides; respiratory disease
Contact
J. A. Hoppin, National Institute of Environmental Health Sciences, Epidemiology Branch, MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709-2233, USA
CODEN
ERJOEI
CAS No.
56-72-4; 76-44-8; 56-38-2; 56-23-5; 75-15-0; 106-93-4; 50-29-3
Publication Date
20091201
Document Type
Journal Article
Email Address
hoppin1@niehs.nih.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0903-1936
NIOSH Division
DRDS
Priority Area
Agriculture, Forestry and Fishing
Source Name
European Respiratory Journal
State
NC; MD; WV
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