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Incorporating genetics and genomics in risk assessment for inhaled manganese: from data to policy.

Authors
Curran-CP; Park-RM; Ho-SM; Haynes-EN
Source
Neurotoxicology 2009 Sep; 30(5):754-760
NIOSHTIC No.
20036084
Abstract
Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body's normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1 mg/m(3)) in air leads to a Parkinsonian syndrome known as "manganism." Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2 mg/m(3)) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed.
Keywords
Airborne-particles; Biochemistry; Biological-monitoring; Biomarkers; Central-nervous-system-disorders; Chemical-hypersensitivity; Exposure-assessment; Exposure-levels; Exposure-methods; Genotoxic-effects; Inhalation-studies; Neurological-reactions; Neurological-system; Neurotoxic-effects; Neurotoxicology; Quantitative-analysis; Author Keywords: Manganese; Occupational health; Epidemiology; Genetic susceptibility; DNA; Policy
Contact
Christine P. Curran, Department of Biological Sciences, Northern Kentucky University, SC342 Nunn Drive, Highland Heights, KY 41099
CODEN
NRTXDN
CAS No.
7439-95-4
Publication Date
20090901
Document Type
Journal Article
Email Address
curranc1@nku.edu
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0161-813X
NIOSH Division
EID
Priority Area
Construction
Source Name
Neurotoxicology
State
OH; KY
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