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Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction.

Authors
Li-D; Zhou-Z; Qing-D; He-Y; Wu-T; Miao-M; Wang-J; Weng-X; Ferber-JR; Herrinton-LJ; Zhu-Q; Gao-E; Checkoway-H; Yuan-W
Source
Hum Reprod 2010 Feb; 25(2):519-527
NIOSHTIC No.
20036067
Abstract
BACKGROUND: Animal studies have suggested that bisphenol-A (BPA) is a potential human endocrine disrupter; but evidence from human studies is needed. METHODS: We conducted an occupational cohort study to examine the effect of occupational exposure to BPA on the risk of male sexual dysfunction. Current workers from BPA-exposed and control factories were recruited. The exposed workers were exposed to very high BPA levels in their workplace. Male sexual function was ascertained through in-person interviews using a standard male sexual function inventory. RESULTS: BPA-exposed workers had consistently higher risk of male sexual dysfunction across all domains of male sexual function than the unexposed workers. After controlling for matching variables and potential confounders, exposed workers had a significantly increased risk of reduced sexual desire [odds ratios (OR) = 3.9, 95% confidence interval: 1.8-8.6), erectile difficulty (OR = 4.5, 95% CI 2.1-9.8), ejaculation difficulty (OR = 7.1, 95% CI 2.9-17.6), and reduced satisfaction with sex life (OR = 3.9, 95% CI 2.3-6.6). A dose-response relationship was observed with an increasing level of cumulative BPA exposure associated with a higher risk of sexual dysfunction. Furthermore, compared with the unexposed workers, BPA-exposed workers reported significantly higher frequencies of reduced sexual function within 1 year of employment in the BPA-exposed factories. CONCLUSIONS: Our findings provide the first evidence that exposure to BPA in the workplace could have an adverse effect on male sexual dysfunction.
Keywords
Reproductive-system-disorders; Sexual-reproduction; Men; Endocrine-function; Epidemiology; Phenols; Occupational-exposure; Questionnaires; Plastic-products; Plastics-industry; Polychlorinated-biphenyls; Epoxy-resins; Author Keywords: bisphenol-A; epidemiology; occupational studies; cohort study
Contact
D. Li, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
CODEN
HUREEE
CAS No.
80-05-7
Publication Date
20100201
Document Type
Journal Article
Email Address
dkl@dor.kaiser.org
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007580
Issue of Publication
2
ISSN
0268-1161
Source Name
Human Reproduction
State
CA; WA
Performing Organization
Kaiser Foundation Research Institute
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