Interpreting longitudinal spirometry: weight gain and other factors affecting the recognition of excessive FEV1 decline.
Wang-ML; Avashia-BH; Petsonk-EL
Am J Ind Med 2009 Oct; 52(10):782-789
Background: Excessive FEV1 loss in an individual or a group can reflect hazardous exposures and development of lung disease. However, multiple factors may affect FEV1 measurements. Methods: Using medical screening data collected in 1884 chemical plant workers between 1973 and 2003, the influence of multiple factors on repeated measurements of FEV1 was examined. Results: The FEV1 level was associated with age, height, race, sex, cigarette smoking, changes in body weight, and spirometer model. After controlling for these factors, longitudinal FEV1 decline averaged 23.8 ml/year for white males; an additional loss of 8.3 ml was associated with one pack-year smoking and 5.4 ml with a one pound weight gain. Depending on the spirometer model, FEV1 differed by up to 95 ml. Conclusions: The study results provide quantitative estimates of the effect of specific factors on FEV1, and should be useful to health professionals in the evaluation of accelerated lung function declines.
Chemical-factory-workers; Chemical-hypersensitivity; Chemical-industry-workers; Chemical-manufacturing-industry; Exposure-assessment; Exposure-levels; Exposure-methods; Health-hazards; Health-surveys; Inhalation-studies; Occupational-exposure; Occupational-hazards; Occupational-health; Occupational-respiratory-disease; Pulmonary-disorders; Pulmonary-system-disorders; Quantitative-analysis; Respiratory-function-tests; Respiratory-hypersensitivity; Respiratory-infections; Respiratory-irritants; Respiratory-system-disorders; Statistical-analysis; Work-analysis; Work-environment; Worker-health; Workplace-studies; Surveillance;
Author Keywords: mass screening; excessive FEV1 decline; spirometry; mixed model; longitudinal data
Edward L. Petsonk, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop H-G900-2,1095 Willowdale Road, Morgantown, WV 26505
American Journal of Industrial Medicine