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Factors afecting initial cholinesterase levels from a pilot study of central Wisconsin farmers.

Authors
Stueland-D; Greenlee-AR
Source
J Agric Saf Health 1999 Nov; 5(4):367-372
NIOSHTIC No.
20035956
Abstract
Measurement of cholinesterase levels can serve as an indirect estimate of exposure to organophosphate or carbamate insecticides. In addition to individual variability, there are potential predictable confounding factors that may affect the result. In a convenience sample of producers that were being evaluated for general health concerns, we performed a pilot study to evaluate parameters that might affect the group cholinesterase levels. Cholinesterase levels were found to be related to the type of grower, even though all claimed not to be exposed at the time of the tests. The plasma and red cell cholinesterase levels did not vary in the same direction between commodity groups. Plasma cholinesterase levels were higher for males than females, but red cell cholinesterase levels were not affected by gender. The plasma cholinesterase levels correlated positively with several tests of liver function whereas the red cell cholinesterase results were negatively correlated with albumin but positively correlated with age. This study underscores the fact that several parameters systematically affect cholinesterase levels. These parameters do not affect both the red cell and plasma cholinesterase similarly. These factors need to be considered when cholinesterase levels are used to compare groups of potentially exposed persons.
Keywords
Agricultural-chemicals; Agricultural-processes; Agricultural-workers; Agriculture; Cholinesterase-inhibitors; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Chemical-structure; Chemical-synthesis; Blood-plasma; Blood-samples; Blood-sampling; Blood-serum; Blood-tests; Blood-analysis; Blood-cells; Exposure-assessment; Exposure-levels; Exposure-limits; Exposure-methods; Insecticides; Health-hazards; Health-protection; Health-standards; Safety-climate; Safety-education; Safety-measures; Safety-monitoring; Safety-personnel; Safety-practices; Author Keywords: Agriculture; Occupational health; Insecticides; Cholinesterase levels
Contact
D.Stueland, Marshfield Medical Research Foundation, Marshfield Clinic, Marshfield, Wis.
CODEN
JASHFD
Publication Date
19991101
Document Type
Journal Article
Email Address
stueland@mfldclin.edu
Funding Amount
249991
Funding Type
Grant
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004073
Issue of Publication
4
ISSN
1074-7583
Priority Area
Disease and Injury: Traumatic Injuries
Source Name
Journal of Agricultural Safety and Health
State
NC
Performing Organization
University of North Carolina, Chapel Hill, North Carolina
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