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Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers.

Authors
Loomis-D; Dement-JM; Wolf-SH; Richardson-DB
Source
Occup Environ Med 2009 Aug; 66(8):535-542
NIOSHTIC No.
20035952
Abstract
OBJECTIVE: To describe mortality among workers exposed to chrysotile asbestos and evaluate the relationship between lung cancer and asbestos fibre exposure. METHODS: Workers employed for at least 1 day between 1 January 1950 and 31 December 1973 in any of four plants in North Carolina, USA that produced asbestos textile products were enumerated. Vital status was ascertained through 31 December 2003. Historical exposures to asbestos fibres were estimated from work histories and 3578 industrial hygiene measurements taken in 1935-1986. Mortality of the cohort was compared with that of the national population via standardised mortality ratios (SMRs). Exposure-response relationships for lung cancer were examined within the cohort using Poisson regression to compute adjusted mortality rate ratios. RESULTS: Follow-up of 5770 workers included in the cohort resulted in 181 640 person-years of observation, with 2583 deaths from all causes and 277 from lung cancer. Mortality from all causes, all cancers and lung cancer was significant higher than expected, with SMRs of 1.47 for all causes, 1.41 for all cancer and 1.96 (95% CI 1.73 to 2.20) for lung cancer. SMRs for pleural cancer, mesothelioma and pneumoconiosis were also elevated. The risk of lung cancer and asbestosis increased with cumulative fibre exposure (RR 1.102 per 100 fibre-year/ml, 95% CI 1.044 to 1.164, and RR 1.249 per 100 fibre-year/ml, 95% CI 1.186 to 1.316, respectively, for total career exposure). CONCLUSIONS: This study provides further evidence that exposure to chrysotile asbestos in textile manufacturing is associated with increased risk of lung cancer, asbestosis cancer of the pleura and mesothelioma.
Keywords
Airborne-dusts; Airborne-fibers; Asbestos-dust; Dust-exposure; Dust-inhalation; Dust-particles; Exposure-assessment; Exposure-levels; Exposure-methods; Fibrous-dusts; Lung-irritants; Lung-disorders; Lung-cancer; Lung-cells; Lung-disease; Mathematical-models; Mesothelial-cells; Mortality-data; Mortality-rates; Mortality-surveys; Occupational-exposure; Occupational-hazards; Occupational-health; Occupational-respiratory-disease; Particulate-dust; Pleural-cavity; Pulmonary-system-disorders; Pulmonary-disorders; Safety-measures; Safety-practices; Work-environment; Work-operations; Work-practices; Work-analysis; Worker-health
Contact
Dana Loomis, School of Community Health Sciences, MS-274, University of Nevada, Reno, NV 89557, USA
CODEN
OEMEEM
CAS No.
12001-29-5; 1332-21-4
Publication Date
20090801
Document Type
Journal Article
Email Address
dploomis@unr.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007803
Issue of Publication
8
ISSN
1351-0711
Source Name
Occupational and Environmental Medicine
State
NC; NV
Performing Organization
University of North Carolina, Chapel Hill
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