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Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.

Authors
Krieg-EF Jr.; Butler-MA; Chang-M-H; Liu-T; Yesupriya-A; Lindegren-ML; Dowling-N
Source
Neurotoxicol Teratol 2009 Nov-Dec; 31(6):364-371
NIOSHTIC No.
20035940
Abstract
The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype.
Keywords
Age-factors; Blood-analysis; Blood-sampling; Blood-serum; Brain-function Chemical-hypersensitivity; Chemical-reactions; Children; Exposure-assessment; Exposure-levels; Exposure-methods; Genes; Genetic-factors; Genetics; Lead-absorption; Neurological-reactions; Statistical-analysis; Author Keywords: Blood lead; Cognitive function; ALAD; Homocysteine; NHANES III
Contact
Edward F. Krieg Jr., Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226-1998
CODEN
NETEEC
CAS No.
7439-92-1
Publication Date
20091101
Document Type
Journal Article
Email Address
erk3@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0892-0362
NIOSH Division
DART
Source Name
Neurotoxicology and Teratology
State
OH
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