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JNK1, a potential therapeutic target for hepatocellular carcinoma.

Authors
Chen-F; Beezhold-K; Castranova-V
Source
Biochim Biophys Acta Bioenerg 2009 Dec; 1796(2):242-251
NIOSHTIC No.
20035908
Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite tremendous efforts to diagnose and institute new treatment regimens, the prognosis is still extremely poor. Therefore, knowledge of the molecular mechanisms governing the initiation, maintenance and progression of HCC is urgently needed. Recently, several groups have attributed an important role for c-Jun N-terminal kinase 1 (JNK1) in the pathogenesis of human HCC and its close association with the expression of HCC signature genes. In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease.
Keywords
Biological-factors; Biomarkers; Cell-biology; Cellular-reactions Cytotoxic-effects; Cytotoxicity; Cytotoxins; Genes; Genetic-factors; Hepatocytes; Liver-cancer; Liver-disorders; Molecular-biology; Molecular-structure; Pathogenesis; Pathogenicity; Pathogens; Author Keywords: JNK1; HCC; Signature genes; ROS; Progenitor cells; Epigenetics
Contact
Fei Chen, Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
Publication Date
20091201
Document Type
Journal Article
Email Address
lfd3@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0005-2728
NIOSH Division
HELD
Priority Area
Manufacturing; Mining
Source Name
Biochimica et Biophysica Acta - Bioenergetics
State
WV
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