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Immune markers and ornithine decarboxylase activity among electric utility workers.

Authors
Ichinose-TY; Burch-JB; Noonan-CW; Yost-MG; Keefe-TJ; Bachand-A; Mandeville-R; Reif-JS
Source
J Occup Environ Med 2004 Feb; 46(2):104-112
NIOSHTIC No.
20035833
Abstract
The effects of a 60-Hz magnetic field (MF) exposure on white blood cell ornithine decarboxylase (ODC) activity, natural killer (NK) cell activity, lymphocyte phenotypes, and differential cell counts were studied among 60 electric utility workers. Personal MF exposure monitoring over 3 consecutive workdays was followed by collection of a peripheral blood sample. There were no MF-related changes in NK activity or the number of circulating neutrophils, eosinophils, basophils, or T-lymphocytes (CD4, CD8, CD4:CD8 ratio). MF exposure intensity was associated with decreased ODC activity (P<0.01) and lower NK cell counts (P=0.04). Melatonin production, which stimulates the immune system, was quantified on the night preceding immune marker determinations. Exposure-related reductions in ODC activity, NK and B cells, and monocytes were strongest among workers with reduced melatonin production. The biological significance or long-term health consequences associated with these changes are not known.
Keywords
Electrical-charge; Electrical-conductivity; Electrical-equipment; Electrical-fields; Electrical-hazards; Electrical-industry; Electrical-insulation; Electrical-measurement; Electrical-properties; Electrical-safety; Electrical-shock; Electrical-stimulation; Electrical-systems; Electrical-transmission; Electrical-waves; Electrical-workers; Electricity; Electromagnetic-absorption; Electromagnetic-energy; Electromagnetic-fields; Electromagnetic-interference; Electromagnetic-radiation; Electromagnetic-wave-transmission; Electron-radiation; Environmental-protection; Exposure-levels; Exposure-limits; Exposure-methods; Blood-analysis; Blood-cells; Blood-disorders; Blood-poisoning; Blood-samples; Blood-sampling; Blood-tests; Chemical-analysis; Chemical-composition; Chemical-hypersensitivity; Chemical-indicators; Chemical-properties; Chemical-reactions; Chemical-structure; Chemical-synthesis; Lymph-glands; Lymph-nodes; Lymphatic-cancer; Education; Electric-power-transmission-lines; Work-analysis; Work-environment; Work-practices; Worker-health; Workers; Workplace-monitoring; Workplace-studies; Safety-climate; Safety-education; Safety-measures; Safety-monitoring; Safety-personnel; Safety-practices; Safety-programs; Health-hazards; Health-programs; Health-protection; Health-services; Health-standards; Immune-reaction; Immune-system; Immune-system-disorders; Immunochemistry; Immunodiagnosis; Magnetic-fields; Magnetic-properties
Contact
T. Y. Ichinose, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523
CODEN
JOEMFM
Publication Date
20040201
Document Type
Journal Article
Email Address
james.burch@colostate.edu
Funding Type
Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007545
Issue of Publication
2
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
CO; GA; WA
Performing Organization
Colorado State University - Fort Collins
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