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Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses.

Authors
Witasp-E; Shvedova-AA; Kagan-VE; Fadeel-B
Source
Inhal Toxicol 2009 Jul; 21(S1):131-136
NIOSHTIC No.
20035776
Abstract
Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities and the application of these materials in a large number of new technologies and consumer products necessitates studies of their potential impact on human health and the environment. To determine whether SWCNT affect viability or function of macrophages, important components of the innate immune system, we performed in vitro studies using primary human monocyte-derived macrophages (HMDM). Our findings show that SWCNT with a low content of metal impurities do not exert direct cytotoxic effects on HMDM. However, SWCNT suppressed chemotaxis of primary human monocytes in a standard chemotaxis assay. Moreover, macrophage engulfment of apoptotic target cells was significantly impaired following pre-incubation of HMDM with SWCNT at non-cytotoxic concentrations. These results are in line with previous studies showing that ultrafine carbon particles and carbon nanotubes may impair alveolar macrophage ingestion of microorganisms, and suggest that tissue homeostasis may be compromised by SWCNT due to suppressive effects on macrophages.
Keywords
Immunology; Immune-system; Immune-reaction; Cytotoxic-effects; Cytotoxicity; Nanotechnology; Author Keywords: Single-walled carbon nanotubes; human monocyte-derived macrophages; phagocytosis; chemotaxis; cytotoxicity
Contact
Bengt Fadeel, MD, PhD, Cell Death Research Group, Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
CODEN
INHTE5
Publication Date
20090701
Document Type
Journal Article
Email Address
bengt.fadeel@ki.se
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282
Issue of Publication
S1
ISSN
0895-8378
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Inhalation Toxicology
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
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