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Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153.

Authors
Chubb-LS; Andersen-ME; Broccardo-CJ; Legare-ME; Billings-RE; Dean-CE; Hanneman-WH
Source
Toxicol Pathol 2004 Jul-Aug; 32(4):467-473
NIOSHTIC No.
20035731
Abstract
Liver enzyme induction has been shown previously to be regional with clear borders between induced and uninduced regions in vivo, and cells either fully induced or not induced in vitro. The current study examined this phenomenon in vivo by evaluating enzyme induction after exposure to PCB 126 and PCB 153 in female Fisher 344 (F344) and male Sprague-Dawley (SD) rats. IHC revealed a regional induction of CYP1A1 after exposure to PCB 126, apparent in the centrilobular region at lower doses and progressing to panlobular with higher doses. PCB 153 exposure induced CYP2B1/2 in the centrilobular region, which spread to the midzonal region as the dose increased, but never became panlobular even at the highest dosage tested. In rats treated with PCB 126 in combination with high doses of PCB 153, induction of CYP1A1 occurred preferentially in the periportal region, a reversal from the pattern seen with PCB 126 alone. This CYP1A1 induction pattern reversal is a unique example of complex biological interactions between coplanar (PCB 126) and noncoplanar (PCB 153) halogenated aromatic hydrocarbons.
Keywords
Agricultural-chemicals; Agricultural-products; Agricultural-workers; Agriculture; Chemical-analysis; Chemical-composition; Chemical-extraction; Chemical-hypersensitivity; Families; Farmers; Entertainment-industry; Entertainment-workers; Environmental-contamination; Environmental-control; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-pollution; Environmental-protection; Environmental-stress; Risk-analysis; Risk-factors; Exposure-assessment; Exposure-levels; Exposure-limits; Safety-climate; Safety-education; Safety-measures; Safety-monitoring; Safety-personnel; Health-hazards; Health-protection; Biological-agents; Biological-effects; Biological-function; Biological-monitoring
Contact
L. S. Chubb, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1680
CODEN
TOPADD
CAS No.
11097-69-1
Publication Date
20040701
Document Type
Journal Article
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007545
Issue of Publication
4
ISSN
0192-6233
Source Name
Toxicologic Pathology
State
CO; NC
Performing Organization
Colorado State University - Fort Collins
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