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Determination of the effective dermal penetration barrier pH of porcine skin.

Authors
Riviere-JE; Brooks-JD
Source
J Vet Pharmacol Ther 2009 Jan; 32(4):407-410
NIOSHTIC No.
20035716
Abstract
The purpose of the present analysis was to determine the operational or effective pH of the skin relative to dermal penetration by using an existing QSPeR model and assessing its best model fit as a function of penetrant's log DpH.
Keywords
Absorption-rates; Acid-mists; Acids; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Dermatitis; Dermatology; Exposure-assessment; Exposure-levels; Exposure-methods; Skin; Skin-absorption; Skin-exposure; Skin-irritants; Skin-sensitivity
Contact
Dr Jim Riviere, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606
CODEN
JVPTD9
Publication Date
20090101
Document Type
Journal Article
Email Address
jim_riviere@ncsu.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007555
Issue of Publication
4
ISSN
0140-7783
Priority Area
Work Environment and Workforce: Mixed Exposures; Manufacturing
Source Name
Journal of Veterinary Pharmacology and Therapeutics
State
WV; MD; NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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