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Incorporating biomarkers into cancer-epidemiology - a matrix of biomarker and study design categories.

Authors
Rothman-N; Stewart-WF; Schulte-PA
Source
Cancer Epidemiol Biomark Prev 1995 Jun; 4(4):301-311
NIOSHTIC No.
20035610
Abstract
During the last decade, there has been increasing interest in the use of biomarkers in cancer epidemiology to enhance exposure assessment, to gain insight into disease mechanism, and to understand acquired or inherited susceptibility. To facilitate the use of biomarkers in health research, biomarkers have been divided into categories that depict the spectrum of cancer pathogenesis from exposure to disease. In this paper, we consider the epidemiological designs most suitable for the study of each type of marker. In particular, we present a two-dimensional matrix relating the biomarker categories on one axis to four different types of activities (laboratory, transitional, and etiological studies and public health applications) that develop markers and apply them in human populations. We then use the matrix to review the potential application of biomarkers in observational studies of cancer etiology, discussing the advantages, disadvantages, and logistical considerations in using biomarkers to answer research questions.
Keywords
Biological-effects; Biological-factors; Biological-monitoring; Biomarkers; Cancer-rates; Exposure-assessment; Exposure-levels; Exposure-methods; Immune-system; Immune-system-disorders; Mathematical-models; Pathogenicity; Risk-factors; Statistical-analysis
Contact
N Rothman, National Cancer Institute, Environmental Epidemiology Branch, Occupation Studies Section, EPN 418, 6130 Executive Boulevard, MSC 7364, Bethesda, MD 20892
CODEN
CEBPE4
Publication Date
19950601
Document Type
Journal Article
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1055-9965
NIOSH Division
DSHEFS
Source Name
Cancer Epidemiology, Biomarkers & Prevention
State
MD; OH
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