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Occupational exposure to magnetic fields and the risk of brain tumors.

Authors
Coble-JB; Dosemeci-M; Stewart-PA; Blair-A; Bowman-J; Fine-HA; Shapiro-WR; Selker-RG; Loeffler-JS; Black-PM; Linet-MS; Inskip-PD
Source
Neuro-Oncology 2009 Jun; 11(3):242-249
NIOSHTIC No.
20035561
Abstract
We investigated the association between occupational exposure to extremely low-frequency magnetic fields (MFs) and the risk of glioma and meningioma. Occupational exposure to MF was assessed for 489 glioma cases, 197 meningioma cases, and 799 controls enrolled in a hospital-based case-control study. Lifetime occupational history questionnaires were administered to all subjects; for 24% of jobs, these were supplemented with job-specific questionnaires, or "job modules," to obtain information on the use of electrically powered tools or equipment at work. Job-specific quantitative estimates for exposure to MF in milligauss were assigned using a previously published job exposure matrix (JEM) with modification based on the job modules. Jobs were categorized as <= 1.5 mG, >1.5 to <3.0 mG, and >= 3.0 mG. Four exposure metrics were evaluated: (1) maximum exposed job; (2) total years of exposure >1.5 mG; (3) cumulative lifetime exposure; and (4) average lifetime exposure. Odds ratios (ORs) were calculated using unconditional logistic regression with adjustment for the age, gender, and hospital site. The job modules increased the number of jobs with exposure >= 3.0 mG from 4% to 7% relative to the JEM. No statistically significant elevation in ORs or trends in ORs across exposure categories was observed using four different exposure metrics for the three tumor types analyzed. Occupational exposure to MFs assessed using job modules was not associated with an increase in the risk for glioma, glioblastoma, or meningioma among the subjects evaluated in this study.
Keywords
Biological-effects; Biological-systems Brain-tumors; Cancer; Cancer-rates; Case-studies; Electrical-equipment; Electric-power-transmission-lines; Electromagnetic-absorption; Electromagnetic-energy; Electromagnetic-fields; Electromagnetic-interference; Electromagnetic-wave-transmission; Environmental-exposure; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Job-analysis; Magnetic-fields; Neurological-reactions; Occupational-exposure; Occupational-health; Occupations; Oncogenicity; Power-tools; Quantitative-analysis; Questionnaires; Risk-analysis; Statistical-analysis; Tumorigenesis; Tumorigens; Work-environment; Worker-health; Work-operations; Work-performance; Author Keywords: glioma; job modules; magnetic fields; meningioma; occupation
Contact
Joseph B. Coble, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20892
CODEN
NEURJR
Publication Date
20081001
Document Type
Journal Article
Email Address
jcoble@mail.nih.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1522-8517
NIOSH Division
DART
Source Name
Neuro-Oncology
State
OH; MD; AZ; PA; MA
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