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Quantitative exposure to metalworking fluids and bladder cancer incidence in a cohort of autoworkers.

Authors
Friesen-MC; Costello-S; Eisen-EA
Source
Am J Epidemiol 2009 Jun; 169(12):1471-1478
NIOSHTIC No.
20035555
Abstract
Occupations with mineral oil exposure have been associated with bladder cancer in population-based case-control studies. The authors report results from the first cohort study to examine bladder cancer incidence in relation to quantitative exposures to metalworking fluids (MWFs), based on 21,999 male Michigan automotive workers, followed from 1985 through 2004. Cox regression was used to estimate hazard ratios based on categorical exposure variables for straight, soluble, and synthetic MWFs, as well as duration of exposure to ethanolamines and nitrosamines. Penalized splines were also fit to estimate the functional form of the exposure-response relation. Increased bladder cancer risk was associated with straight MWFs but not with any other exposure. The hazard ratio increased with cumulative exposure to a maximum of 2-fold observed at 75 mg/m(3)-year straight MWF exposure (lagged 20 years). Calendar time windows relevant to polycyclic aromatic hydrocarbon exposure were examined but could not be distinguished from the lagged (10-, 20-year) metrics. No association was observed between any exposure and incident lung cancer, suggesting that smoking is unlikely to confound the associations observed here. The quantitative relation with straight MWFs strengthens the evidence for mineral oils as a bladder carcinogen.
Keywords
Airborne-particles; Automotive-industry; Biohazards; Biological-monitoring; Biological-systems; Bladder-cancer; Bladder-disease; Bladder-disorders; Cancer; Cancer-rates; Chemical-hypersensitivity; Chemical-properties; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Metal-compounds; Metal-industry-workers; Metal-poisoning; Metal-workers; Metalworking-fluids; Metalworking-industry; Occupational-diseases; Occupational-exposure; Occupational-hazards; Occupational-health; Quantitative-analysis; Respiratory-irritants; Risk-analysis; Statistical-analysis; Urogenital-system-disorders; Work-environment; Work-operations; Worker-health; Workplace-studies; Author Keywords: cohort studies; Cox model; ethanolamines; lung neoplasms; mineral oil; nitrosamines; polycyclic hydrocarbons; aromatic; urinary bladder neoplasms
Contact
Dr. Ellen A. Eisen, Environmental Health Sciences Division, School of Public Health, University of California, 50 University Hall, #7360, Berkeley, CA 94720-7360
CODEN
AJEPAS
CAS No.
141-43-5; 479-45-8
Publication Date
20090615
Document Type
Journal Article
Email Address
eeisen@berkeley.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008927
Issue of Publication
8
ISSN
0002-9262
Source Name
American Journal of Epidemiology
State
CA; MD
Performing Organization
University of California, Berkeley
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