Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The differential effects of the herbicide Banvel (Dicamba) on peroxisomal and cytochrome P-450 activities.

Authors
Espandiari-P; Thomas-VA; Robertson-LW
Source
Toxicologist 1994 Mar; 14(1):388
NIOSHTIC No.
20035554
Abstract
The widely used broad leaf herbicide Banvel is similar in structure to xenobiotics which induce hepatic drug metabolism or proliferation of hepatic peroxisomes. The ability of xenobiotics to effect these hepatic changes often portends their positive outcomes in rodent chronic bioassays. Banvel's ability to induce hepatomegaly, peroxisome proliferation and drug metabolism was studied in male and female Sprague Dawley rats. Rats were placed on feed containing 0.001, 0.01, 0.1, and 1% Banvel or 0.01% ciprofibnate for 3 weeks. Banvel had no effect on relative liver weight or feed efficiency in either female or male rats at all doses tested. Banvel caused a statistically significant increase in peroxisomal B-oxidation in female rats only at 1 % dietary level. Banvel significantly decreased ethoxyresondin O-deethylase activity at several doses while benzoloxyresorufin O-debenzylase activity was increased at the highest dose of Banvel in both female and male rats. Lauric acid hydroxylase activity was increased in microsomes from male rats fed the highest level of Banvel.
Keywords
Laboratory-testing; Toxins; Toxicology; Toxic-effects; Exposure-assessment; Exposure-levels; Animal-studies; Laboratory-animals; Herbicides; Dietary-effects
CAS No.
1918-00-9
Publication Date
19940301
Document Type
Abstract
Funding Amount
914815
Funding Type
Cooperative Agreement
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-408035
Issue of Publication
1
ISSN
0731-9193
Source Name
The Toxicologist. Society of Toxicology 33rd Annual Meeting, March 13-17, 1994, Dallas, Texas
State
OH
Performing Organization
University of Kentucky, Department of Preventive Medicine, Lexington, KY
TOP