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Efficacy of a program to prevent beryllium sensitization among new employees at a copper-beryllium alloy processing facility.

Authors
Thomas-CA; Bailey-RL; Kent-MS; Deubner-DC; Kreiss-K; Schuler-CR
Source
Public Health Rep 2009 Jul-Aug; 124(Suppl 1):112-124
NIOSHTIC No.
20035541
Abstract
Objectives. In 2000, 7% of workers at a copper-beryllium facility were beryllium sensitized. Risk was associated with work near a wire annealing/pickling process. The facility then implemented a preventive program including particle migration control, respiratory and dermal protection, and process enclosure. We assessed the program's efficacy in preventing beryllium sensitization. Methods. In 2000, the facility began testing new hires (program workers) with beryllium lymphocyte proliferation tests (BeLPTs) at hire and at intervals during employment. We compared sensitization incidence rates (IRs) and prevalence rates for workers hired before the program (legacy workers) with rates for program workers, including program worker subgroups. We also examined trends in BeLPTs from a single laboratory. Results. In all, five of 43 legacy workers (IR53.8/1,000 person-months) and three of 82 program workers (IR51.9/1,000 person-months) were beryllium sensitized, for an incidence rate ratio (IRR) of 2.0 (95% confidence interval [CI] 0.5, 10.1). Two of 37 pre-enclosure program workers (IR52.4/1,000 person-months) and one of 45 post-enclosure program workers (IR51.4/1,000 person-months) were beryllium sensitized, for IRRs of 1.6 (95% CI 0.3, 11.9) and 2.8 (95% CI 0.4, 66.2), respectively, compared with legacy workers. Test for trend in prevalence rates was significant. Among 2,159 first-draw BeLPTs during 95 months, we identified seven months when high numbers of redraws were required, with one possible misclassification in this facility. Conclusions. Fewer workers became sensitized after implementation of the preventive program. However, low statistical power due to the facility's small workforce prevents a definitive conclusion about the program's efficacy. These findings have implications for other copper-beryllium facilities, where program components may merit application.
Keywords
Chemical-factory-workers; Chemical-hypersensitivity; Chemical-industry-workers; Chemical-properties; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Inhalation-studies; Injury-prevention; Laboratory-testing; Occupational-exposure; Occupational-hazards; Occupational-health; Occupational-health-programs; Safety-programs; Statistical-analysis; Work-analysis; Work-areas; Work-environment; Worker-health; Work-operations; Workplace-studies; Work-practices
Contact
Carrie A. Thomas, PhD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, 1095 Willowdale Rd., MS-2800, Morgantown, WV 26505
CODEN
PHRPA6
CAS No.
7440-50-8; 7440-41-7
Publication Date
20090701
Document Type
Journal Article
Email Address
Carrie.Thomas@cdc.hhs.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
ISSN
0033-3549
NIOSH Division
DRDS
Priority Area
Manufacturing
Source Name
Public Health Reports
State
WV
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